Video Bioinformatics

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<div>The advances of live cell video imaging and high-throughput technologies for functional and chemical&nbsp;genomics provide unprecedented opportunities to understand how biological processes work in subcellular</div><div>and multicellular systems. The interdisciplinary research field of Video Bioinformatics is defined by Bir</div><div>Bhanu as the automated processing, analysis, understanding, data mining, visualization, query-based</div><div>retrieval/storage of biological spatiotemporal events/data and knowledge extracted from dynamic images</div><div>and microscopic videos. Video bioinformatics attempts to provide a deeper understanding of continuous</div><div>and dynamic life processes.</div><div>Genome sequences alone lack spatial and temporal information, and video imaging of specific molecules</div><div>and their spatiotemporal interactions, using a range of imaging methods, are essential to understand</div><div>how genomes create cells, how cells constitute organisms, and how errant cells cause disease. The book</div><div>examines interdisciplinary research issues and challenges with examples that deal with organismal dynamics,</div><div>intercellular and tissue dynamics, intracellular dynamics, protein movement, cell signaling and software</div><div>and databases for video bioinformatics.</div><div>Topics and Features</div><div>• Covers a set of biological problems, their significance, live-imaging experiments, theory and</div><div>computational methods, quantifiable experimental results and discussion of results.</div><div>• Provides automated methods for analyzing mild traumatic brain injury over time, identifying injury</div><div>dynamics after neonatal hypoxia-ischemia and visualizing cortical tissue changes during seizure</div><div>activity as examples of organismal dynamics</div><div>• Describes techniques for quantifying the dynamics of human embryonic stem cells with examples</div><div>of cell detection/segmentation, spreading and other dynamic behaviors which are important for</div><div>characterizing stem cell health</div><div>• Examines and quantifies dynamic processes in plant and fungal systems such as cell trafficking,</div><div>growth of pollen tubes in model systems such as Neurospora Crassa and Arabidopsis</div><div>• Discusses the dynamics of intracellular molecules for DNA repair and the regulation of cofilin</div><div>transport using video analysis</div><div>• Discusses software, system and database aspects of video bioinformatics by providing examples of</div><div>5D cell tracking by FARSIGHT open source toolkit, a survey on available databases and software,</div><div>biological processes for non-verbal communications and identification and retrieval of moth images</div><div>This unique text will be of great interest to researchers and graduate students of Electrical Engineering,</div><div>Computer Science, Bioengineering, Cell Biology, Toxicology, Genetics, Genomics, Bioinformatics, Computer</div><div>Vision and Pattern Recognition, Medical Image Analysis, and Cell Molecular and Developmental Biology.</div><div>The large number of example applications will also appeal to application scientists and engineers.</div><div>Dr. Bir Bhanu is Distinguished Professor of Electrical &amp; C omputer Engineering, Interim Chair of the</div><div>Department of Bioengineering, Cooperative Professor of Computer Science &amp; Engineering, and Mechanical</div><div>Engineering and the Director of the Center for Research in Intelligent Systems, at the University of California,</div><div>Riverside, California, USA.</div><div>Dr. Prue Talbot is Professor of Cell Biology &amp; Neuroscience and Director of the Stem Cell Center and Core at</div><div>the University of California Riverside, California, USA.</div>