Proteoglycans in Stem Cells

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<p>This book provides a state-of-the-art compendium on the role of proteoglycans and glycosaminoglycans during development and in cancer. It also suggests directions for novel therapeutic and biotechnological applications in stem cell biology. <br> Proteoglycans and glycosaminoglycans, as part of the extracellular matrix, are multifunctional modulators of growth factor, cytokine, integrin and morphogen signaling, which determine both self-renewal, senescence and/or differentiation of stem cells during development. Since proteoglycans modulate cell adhesion and migration they are important organizers of the extracellular matrix within the proper stem cell niche. A malfunctioning of proteoglycans and glycosaminoglycans contributes to the cancer stem cell phenotype, which is linked to therapeutic resistance and recurrence in malignant disease. <br> This book is essential reading for anyone interested in the extracellular matrix and its role in development.</p> <p>The series <i>Biology of Extracellular Matrix</i> is published in collaboration with the American Society for Matrix Biology.<br></p> <p><br></p> <br> <p></p>